FDA-approved nasal spray for Depression
Let’s Change and Improve Brain Health through Spravato®

Reasons to consider
Spravato® is an FDA-approved nasal spray for treatment-resistant depression; it is also approved to treat depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions. It was approved by the FDA in 2019. Spravato® (esketamine) CIII nasal spray is a derivative of ketamine.
Rapid Relief of Symptoms
Many patients report noticeable improvements within hours or days of their first treatment, even though they have not benefitted from medications before. Spravato® is added on to the antidepressant you are already taking.
Highly Effective & Keeps on Working
1. Research shows that when Spravato® is added on to an antidepressant it is much more likely to work than a typical augmenting agent.
2. Research also shows Spravato® is less likely to stop working than other agents. With Spravato® 75% patients are maintaining antidepressant effectiveness at five years, whereas for those with treatment resistant depression, medications usually do not continue to work with less than 20% still getting help after one year.
It’s Different: It Works on the Glutamate System of the Brain:
Because Spravato® is an NMDA receptor antagonist, it alters brain glutamate levels. It provides a truly different mechanism of action to try when Serotonin, Norepinephrine and Dopamine medications have failed to help.
Rapid Relief of Symptoms
Many patients report noticeable improvements within hours or days of their first treatment, even though they have not benefitted from medications before. Spravato® is added on to the antidepressant you are already taking.
Can Reduce Suicidal Thoughts
Research indicates that Spravato® can quickly decrease the severity of suicidal thoughts. It provides critical support for individuals in acute distress and potentially prevents tragic outcomes.
Medicaid and Medicare are accepted
Effective and Covered by Insurance for those with:
- 1. Treatment Resistant Depression (failure of improvement with two previous antidepressant medications).
- 2. Depressive symptoms of Major Depressive Disorder with acute suicidal ideation or behavior.
Convenience of Administration
No needles or daily pills. Spravato® is self-administered as a nasal spray in a registered clinic, twice a week for the first month and less frequently, once a week to one a month after that, making it a practical option for many.
Reasons to consider Southern Colorado TMS for Spravato®:
- 1. Physician led clinic.
- 2. Extensive experience.
- 3. Simple assessment to determine your eligibility.
- 4. Prior Authorization services provided at no change after the assessment.
- 5. We can help you compare and choose between various options: Spravato, IV Ketamine, TMS and new medication trials. Not just a one option clinic.
- 6. Offering ketamine since 2014 and TMS since 2011.

Begin Now!
If you want to consider Spravato® to help with your condition, contact us